The Science and Ethics of HIV Vaccine Research
Our HIV Vaccines Curriculum Unit explores the scientific and ethical issues involved in clinical HIV vaccine trials using human research participants. The unit begins by examining students’ current knowledge of HIV, and by reviewing HIV structure and transmission. Next, it familiarizes students with types of vaccines and with challenges related to creating an HIV vaccine. Students are encouraged to explore issues related to human research participants using basic ethical principles and historical case studies. Lastly, global issues regarding the pandemic are explored to give the students an understanding of cultural issues involved in the spread of HIV. This cultural context introduces students to ethical dilemmas inherent in the selection of human participants in global vaccine trials. The lessons culminate in having students design their own hypothetical HIV vaccine clinical trial, based upon knowledge of HIV structure, vaccine characteristics, human research participants considerations, and global contexts.
The complete five-lesson HIV Vaccines Curriculum is now available free for download from the Lessons page.
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This curriculum is available free of charge, but for demographic purposes, NWABR requests you fill out a short information form.
Complete Lesson Plans
Complete Curriculum ENTIRECIRRICULUM_2008.pdf
Overall Unit Plan
Correlation to National Science Standards
Lesson One - What Do You Know and What Will You Do? LESSONONE_2008.pdf
Lesson Plan One
What Would You Do? Opening Scenario
Global Awareness of HIV Survey
Avert Transmission Activity
Pandemic Facing AIDS Video Questions
Lesson Two - HIV Structure/Life Cycle--Implications for Vaccine Development LESSONTWO_2008.pdf
Lesson Plan Two
HIV Life Cycle Activity
Lesson Three - Vaccines LESSONTHREE_2008.pdf
Lesson Plan Three
Vaccine Type Table
Lesson Four - Case Studies and Human Research Ethics LESSONFOUR_2008.pdf
Lesson Plan Four
Case Study 1: Yellow Fever
Case Study 2: Nazi Experiments
Case Study 3: Syphilis in African-American Men
Case Study 4: AZT and Pregnant Women in Africa
Case Study 5: Behaviour in Young Boys
Historical Case Studies for Human Research Guiding Questions
Student Handouts for Guidelines Activity
Lesson Five - Global Awareness Activity LESSONFIVE_2008.pdf
Lesson Plan Five
Global Awareness Activity Region and Country Cards
Front Cover COVER_2008.pdf
Culminating Assessments Overview
Presentation Student Introduction--Designing a Vaccine Trial
Group Presentation Rubric
Alternate Assessment--Evaluating an IRB Application
Key for Alternate Assessment
Declaration of Helsinki
Review of HIV
Review of Immune System
Making an HIV Vaccine
HIV Preventative Vaccine Background
HIV Vaccine Brochure
HIV Mock Elisa Lab Activity HIV_MOCK_ELISA.doc
Understanding Vaccines NIH Pamphlet Understanding_Vaccines_NIH_Pamphlet.pdf
NWABR HIV Slideshow/Animations
Designed to be used with our HIV Vaccine Curriculum, these new slideshow/animations made in collaboration with the Genetic Science Learning Center show two different aspects of vaccines.
Types of Vaccines
What are the different types of vaccines? What are the advantages and disadvantages of each type? Which types are being pursued for an HIV vaccine?
Why is Making an HIV Vaccine so Hard?
This interactive animation explores the scientific challenges faced by researchers in developing an HIV vaccine.
HIV Vaccine Research Powerpoint
By: Dr. Dina Kovarik, NWABR Program Manager